Molecular Neurobiology of Alzheimer Disease and Related Disorders
By Masatoshi Takeda, Toshihisa Tanaka, Ramon Cacabelos
Publisher: S. Karger Publishers (USA)
Number Of Pages: 297
Publication Date: 2004-04
ISBN-10 / ASIN: 380557603X
ISBN-13 / EAN: 9783805576031
Alzheimers disease affects 6 10% of the elderly population, causing impairment in cognitive functions and significant disability in daily living for more than ten years. Neurofibrillary tangles, amyloid deposits and neuronal loss are the three hallmarks of Alzheimers disease. Due to insolubility of these unique structures in Alzheimer brain tissue, they were very difficult to study by usual biochemical methods in the past. Active research is now going on to elucidate the pathogenesis of Alzheimers disease. Major topics of neurobiological study of Alzheimers disease include the unraveling of the molecular mechanism of neurofibrillary tangle formation in neuronal and glial cells, the molecular processing of amyloid precursor protein in intracellular organella and in extra-cellular space, and the molecular mechanism of neuronal loss.