Posted by: saadessa | فبراير 27, 2008

Pharmacokinetic-Pharmacodynamic Modeling and Simulation

Pharmacokinetic-Pharmacodynamic Modeling and Simulation
By Peter Bonate

  • Publisher: Springer
    Number Of Pages: 387
    Publication Date: 2005-10-20
    ISBN-10 / ASIN: 038727197X
    ISBN-13 / EAN: 9780387271972
  • Binding: Hardcover

Book Description:

A natural hierarchy exists in pharmacokinetic-pharmacodynamic modeling culminating in population pharmacokinetic models, which are a specific type of nonlinear mixed effects model. The purpose of this book is to present through theory and example how to develop pharmacokinetic models, both at an individual and population level. In order to do so, however, one must first understand linear models and then build to nonlinear models followed by linear mixed effects models and then ultimately nonlinear mixed effects models. This book develops in that manner each chapter builds upon previous chapters by first presenting the theory and then illustrating the theory using published data sets and actual data sets that were used in the development of new chemical entities collected by the author during his years in industry. A key feature of the book is the process of modeling.

http://www.book4doc.com/16892


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